Dr Sara Lopez-Gomollon

My fundamental question is 'how are genes regulated?'. In my PhD at the University of Zaragoza (Spain), I studied transcription factors in cyanobacteria, followed by postdoctoral research on plant miRNAs with Professor Tamas Dalmay at the University of East Anglia and other small (s)RNAs with Professor Sir David Baulcombe at the University of Cambridge. 

In 2019, I was awarded a Broodbank Research Fellowship at the University of Cambridge. In my research investigating how plants adapt to hybridisation and the genome shock associated, we discovered a novel mechanism that associates regulatory sRNAs with a type of transposable elements, and these with regulation of gene expression that can be related to those different phenotypes that are present in hybrids. 

I joined the University of Kent in 2023. My group focuses on gene regulation in response to the environment and the molecular mechanisms behind it.

At the Plant RNA Biology group, we explore the fascinating world of plant gene regulation. Our mission is to unravel the intricate dance of gene expression in response to internal and external cues, operating at both transcriptional and posttranscriptional levels. Led by Sara Lopez-Gomollon, our research is centered around the dynamic interplay of small RNAs and epigenetic mechanisms, with the versatile tomato plant as our model organism. 

Through rigorous experimentation and cutting-edge techniques, we strive to decode the molecular language governing gene regulation in plants. One of our flagship projects investigates endogenous pararetroviruses (EPRVs), dormant fragments of ancient viruses embedded within plant genomes. When triggered by a stress, these latent genetic relics can reawaken, potentially leading to viral disease. The plant, however, has evolved a sophisticated response to silence them mediated by small RNAs, albeit with downstream consequences on gene expression. This delicate balance between survival and adaptation is at the heart of our exploration. 

Employing a diverse array of methodologies, from classical molecular biology techniques to state-of-the-art CRISPR-based (epi)genomic tools, we dissect the genome-wide dynamics underlying these phenomena. Our research tools also include transient and stable transformation methods, along with cutting-edge genomics, epigenomics, and bioinformatics, providing us with a comprehensive toolkit to address the complex questions we pose. 

Ultimately, our aim extends beyond scientific curiosity. We envision a future where our insights pave the way for advancements in plant breeding. By enhancing our understanding of these fundamental mechanisms, we strive to contribute to the development of more robust and resilient crops, able to meet the challenges of a changing world. Join us in our quest to unlock the secrets of plant gene regulation and be part of a vibrant community dedicated to shaping the future of agricultural innovation.  

Academic advisor at Biosciences Academic Advising and Skills Development I (BIOS4000)  

Our lab is open to new members! Contact me if you are interested in being part of it.